Tg(Myh6-Ppara)404-3Dpk
Transgene Detail

Summary

• Symbol: Tg(Myh6-Ppara)404-3Dpk
• Name: transgene insertion 404-3, Daniel P Kelly
• MGI ID: MGI:3641575
• Synonyms: MHC-PPAR, MHC-PPARalpha
• Transgene: Tg(Myh6-Ppara)404-3Dpk Location: unknown
• Alliance: Tg(Myh6-Ppara)404-3Dpk page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Ppara)404-3Dpk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppara (MGI:104740)

• Mutation details: This transgene consists of a 1.5-kb, NH2-terminal FLAG epitope-tagged Ppara cDNA downstream of the cardiac alpha myosin heavy chain promoter. This line exhibits Ppara protein levels about 135-fold more abundant in cardiac ventricles than in nontransgenics. (J:110580)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:110580 Finck BN, et al., The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002 Jan;109(1):121-30
• All: 10 reference(s)