Pdpn^tm1Bwd
Targeted Allele Detail

Summary

• Symbol: Pdpn^tm1Bwd
• Name: podoplanin; targeted mutation 1, Lynda F Bonewald
• MGI ID: MGI:3641576
• Gene: Pdpn Location: Chr4:142994001-143026134 bp, - strand Genetic Position: Chr4, 77.29 cM
• Alliance: Pdpn^tm1Bwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109608
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette replaced exon 1 and part of intron 1 of the locus. LoxP sites flanked the neo. Mutant embryos expressed lacZ in the dorsal spinal cord, in the lung bud and in the developing choroids plexus. In the newborn, high expression was observed in osteocytes, but surprisingly not in tissues shown to express Pdpn, such as lung and kidney. (J:109608)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpn Mutation: 29 strains or lines available

References

• Original: J:109608 Zhang K, et al., E11/gp38 selective expression in osteocytes: Regulation by mechanical strain and role in dendrite elongation. Mol Cell Biol. 2006 Jun;26(12):4539-52
• All: 1 reference(s)