Tg(CAMK2A-CAST)7Tcs
Transgene Detail

Summary

• Symbol: Tg(CAMK2A-CAST)7Tcs
• Name: transgene insertion 7, Takaomi C Saido
• MGI ID: MGI:3652380
• Transgene: Tg(CAMK2A-CAST)7Tcs Location: unknown
• Alliance: Tg(CAMK2A-CAST)7Tcs page

Transgene origin

• Strain of Origin: C57BL/6Cr

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAMK2A-CAST)7Tcs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CAST (831)

  Cast	(MGI:1098236)

• Mutation details: The human calpastatin cDNA was cloned into a vector containing the calcium/calmodulin-dependent protein kinase-II alpha subunit promoter. Analysis showed that human calpastatin was robustly expressed in the hippocampus and neocortex of transgenic mice. (J:109976)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:109976 Takano J, et al., Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. J Biol Chem. 2005 Apr 22;280(16):16175-84
• All: 4 reference(s)