Lta^tm1.1Sned
Targeted Allele Detail

Summary

• Symbol: Lta^tm1.1Sned
• Name: lymphotoxin A; targeted mutation 1.1, Sergei A Nedospasov
• MGI ID: MGI:3652393
• Synonyms: Lta^delta
• Gene: Lta Location: Chr17:35422141-35424327 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta^tm1.1Sned page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire locus was removed via homologous recombination. Flow cytometry confirmed absence of Lt surface expression. (J:109621)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lta Mutation: 17 strains or lines available

References

• Original: J:109621 Liepinsh DJ, et al., Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Mol Cell Biol. 2006 Jun;26(11):4214-25
• All: 4 reference(s)