Clock^tm1.1Rep
Targeted Allele Detail

Summary

• Symbol: Clock^tm1.1Rep
• Name: clock circadian regulator; targeted mutation 1.1, Steven M Reppert
• MGI ID: MGI:3652400
• Synonyms: Clock^delta5-6, Clock^tm1.1Drw
• Gene: Clock Location: Chr5:76357715-76452639 bp, - strand Genetic Position: Chr5, 40.63 cM
• Alliance: Clock^tm1.1Rep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109634
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination resulted in the excision of exons 5 and 6. Immunohistochemistry confirmed absence of protein in mutants. (J:109634)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clock Mutation: 104 strains or lines available

References

• Original: J:109634 Debruyne JP, et al., A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4;50(3):465-77
• All: 20 reference(s)