Mib2^tm1Art
Targeted Allele Detail

Summary

• Symbol: Mib2^tm1Art
• Name: mindbomb E3 ubiquitin protein ligase 2; targeted mutation 1, Karen Artzt
• MGI ID: MGI:3652500
• Gene: Mib2 Location: Chr4:155739134-155753655 bp, - strand Genetic Position: Chr4, 86.86 cM
• Alliance: Mib2^tm1Art page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129104
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 11 exons were replaced with a beta-geo cassette. This deletion removes most of the ankyrin repeats and authors state that this is a null allele. RT-PCR confirmed that the exons were removed. (J:129104)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mib2 Mutation: 61 strains or lines available

References

• Original: J:129104 Wu JI, et al., Targeted disruption of Mib2 causes exencephaly with a variable penetrance. Genesis. 2007 Nov;45(11):722-7
• All: 2 reference(s)