Myh6^tm1Rbns
Targeted Allele Detail

Summary

• Symbol: Myh6^tm1Rbns
• Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins
• MGI ID: MGI:3652543
• Synonyms: alpha-MyHC^-
• Gene: Myh6 Location: Chr14:55179378-55204384 bp, - strand Genetic Position: Chr14, 28.01 cM
• Alliance: Myh6^tm1Rbns page

Fibrotic lesions in Myh6^tm1Rbns/Myh6⁺ hearts

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36089
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo-pA cassette replaced the 5' UTR, the start sites of transcription and translation and the first 3 exons of the locus. (J:36089)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh6 Mutation: 206 strains or lines available

References

• Original: J:36089 Jones WK, et al., Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest. 1996 Oct 15;98(8):1906-17
• All: 3 reference(s)