Igkc^tm1Bgmn
Targeted Allele Detail

Summary

• Symbol: Igkc^tm1Bgmn
• Name: immunoglobulin kappa constant; targeted mutation 1, Marianne Bruggemann
• MGI ID: MGI:3652576
• Synonyms: Kappa^-
• Gene: Igkc Location: Chr6:70703419-70703738 bp, + strand Genetic Position: Chr6, 32.04 cM, cytoband C
• Alliance: Igkc^tm1Bgmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28868
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance gene was inserted into the gene by homologous recombination. (J:28868)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igkc Mutation: 9 strains or lines available

References

• Original: J:28868 Zou X, et al., Subtle differences in antibody responses and hypermutation of lambda light chains in mice with a disrupted chi constant region. Eur J Immunol. 1995 Aug;25(8):2154-62
• All: 7 reference(s)