Csf2rb2^tm1Cgb
Targeted Allele Detail

Summary

• Symbol: Csf2rb2^tm1Cgb
• Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage); targeted mutation 1, C Glenn Begley
• MGI ID: MGI:3652583
• Synonyms: Betail3^-, BIL3^-
• Gene: Csf2rb2 Location: Chr15:78166707-78189921 bp, - strand Genetic Position: Chr15, 37.22 cM
• Alliance: Csf2rb2^tm1Cgb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32978
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 9-13 were replaced with a neomycin resistance cassette. (J:32978)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Csf2rb2 Mutation: 47 strains or lines available

References

• Original: J:32978 Nicola NA, et al., Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells. Blood. 1996 Apr 1;87(7):2665-74
• All: 19 reference(s)