Fli1^tm1Ber
Targeted Allele Detail

Summary

• Symbol: Fli1^tm1Ber
• Name: Friend leukemia integration 1; targeted mutation 1, Alan Bernstein
• MGI ID: MGI:3652588
• Synonyms: Fli-1^-
• Gene: Fli1 Location: Chr9:32333500-32454157 bp, - strand Genetic Position: Chr9, 17.74 cM
• Alliance: Fli1^tm1Ber page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33052
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resisitance gene replaced exon 2 such that the resulting frame shift mutation would disrupt all but the first 10 amino acids of the protein. Western blot confirmed absence of protein in mutant spleens. (J:33052)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fli1 Mutation: 26 strains or lines available

References

• Original: J:33052 Melet F, et al., Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia. Mol Cell Biol. 1996 Jun;16(6):2708-18
• All: 1 reference(s)