Il3ra^m1
Spontaneous Allele Detail

Summary

• Symbol: Il3ra^m1
• Name: interleukin 3 receptor, alpha chain; mutation 1
• MGI ID: MGI:3652833
• Synonyms: Il3ra^A/J, Il3raⁿ
• Gene: Il3ra Location: Chr14:8114270-8123851 bp, - strand Genetic Position: Chr14, 7.08 cM
• Alliance: Il3ra^m1 page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Sequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7. (J:23971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 12 strains available Cell Lines: 0 lines available
• Carrying any Il3ra Mutation: 38 strains or lines available

Notes

This allele has been identified in A/J, A/WySnJ, A/HeJ, C58/J, RF/J, AKR/J, SM/J, BUB/BnJ, CE/J, and NZB/B1NJ. see J:24918.

References

• Original: J:23971 Ichihara M, et al., Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J. 1995 Mar 1;14(5):939-50
• All: 3 reference(s)