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Macf1tm1Liem
Targeted Allele Detail
Summary
Symbol: Macf1tm1Liem
Name: microtubule-actin crosslinking factor 1; targeted mutation 1, Ronald K H Liem
MGI ID: MGI:3652899
Synonyms: Macf1-
Gene: Macf1  Location: Chr4:123243426-123581331 bp, - strand  Genetic Position: Chr4, 57.42 cM
Alliance: Macf1tm1Liem page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110693
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette was inserted to replace part of exons 25 and 28 and all of exons 26 and 27. The targeted sequence encoded amino acids 1053-1230, common to all isoforms. (J:110693)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Macf1 Mutation:  854 strains or lines available
References
Original:  J:110693 Chen HJ, et al., The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory