Rp1^tm1Eap
Targeted Allele Detail

Summary

• Symbol: Rp1^tm1Eap
• Name: retinitis pigmentosa 1 (human); targeted mutation 1, Eric A Pierce
• MGI ID: MGI:3652902
• Synonyms: Rp1b^tm1Eap, Rp1-myc, Rp1^myc
• Gene: Rp1 Location: Chr1:4185896-4479508 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Rp1^tm1Eap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85754
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to truncate the coding sequence after codon 662 in exon 4. A 10 amino acid myc tag was incorporated at the 3' end of the truncated exon 4. (J:85754)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rp1 Mutation: 121 strains or lines available

References

• Original: J:85754 Liu Q, et al., RP1 is required for the correct stacking of outer segment discs. Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4171-83
• All: 4 reference(s)