Gja1^tm1.1Gfi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm1.1Gfi
• Name: gap junction protein, alpha 1; targeted mutation 1.1, Glenn I Fishman
• MGI ID: MGI:3652926
• Synonyms: Cx43^-, Cx43^fo
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm1.1Gfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108525
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The floxed exon 2 from Gja1^tm1Gfi was removed via homologous recombination. (J:108525)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:108525 Liu S, et al., Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development. 2006 May;133(10):2063-73
• All: 2 reference(s)