Ilk^tm3Ref
Targeted Allele Detail

Summary

• Symbol: Ilk^tm3Ref
• Name: integrin linked kinase; targeted mutation 3, Reinhard Fassler
• MGI ID: MGI:3653044
• Synonyms: Ilk^flox
• Gene: Ilk Location: Chr7:105385799-105392132 bp, + strand Genetic Position: Chr7, 55.97 cM, cytoband E1
• Alliance: Ilk^tm3Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110783
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 2 with loxP sites such that Cre-mediated recombination would ablate gene expression. (J:82761, J:110783)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ilk Mutation: 18 strains or lines available

References

• Original: J:110783 Grashoff C, et al., Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep. 2003 Apr;4(4):432-8
• All: 23 reference(s)