Ren1^tm1Tkh
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1Tkh
• Name: renin 1 structural; targeted mutation 1, Nobuyuki Takahashi
• MGI ID: MGI:3653266
• Synonyms: Ren1c-
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1Tkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110082
• Parent Cell Line: CMTI-2 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment including the promoter and exons 1-6 was replaced with a neo cassette via homologous recombination. No renin is detected in the plasma of homozygotes. (J:110082)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 35 strains or lines available

References

• Original: J:110082 Takahashi N, et al., Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol. 2005 Jan;16(1):125-32
• All: 8 reference(s)