Inhbe^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Inhbe^tm1Zuk
• Name: inhibin beta-E; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:3653272
• Synonyms: actbetaE^m1, Inhbc^tm2Zuk
• Gene: Inhbe Location: Chr10:127185271-127187717 bp, - strand Genetic Position: Chr10, 74.5 cM
• Alliance: Inhbe^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110815
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7 kb fragment including the entire coding region was replaced with a floxed PGK-neo cassette. This line was created with ES cells that were also heterozygous for Inhbc^tm1Zuk. This insertion is in cis and was used to create the double mutation. (J:110815)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inhbe Mutation: 12 strains or lines available

References

• Original: J:110815 Lau AL, et al., Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration. Mol Cell Biol. 2000 Aug;20(16):6127-37
• All: 2 reference(s)