Igh^tm4Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm4Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 4, Michel Cogne
• MGI ID: MGI:3653375
• Synonyms: fr-Vkappa, IgH^frVkappa
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109988
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert an out of frame fr-Vkappa exon and neomycin resistance gene cassette between the JH region and Emu. The floxed neo was subsequently removed via cre-mediated recombination. (J:109988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:109988 Reynaud S, et al., Interallelic class switch recombination contributes significantly to class switching in mouse B cells. J Immunol. 2005 May 15;174(10):6176-83
• All: 3 reference(s)