Pten^tm1.1Hwu
Targeted Allele Detail

Summary

• Symbol: Pten^tm1.1Hwu
• Name: phosphatase and tensin homolog; targeted mutation 1.1, Hong Wu
• MGI ID: MGI:3653378
• Synonyms: Pten^-, Pten^delta5
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1.1Hwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110567
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cells were transiently transfected with cre recombinase for removal of floxed exon 5 from the locus. (J:110567)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1.1Hwu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:110567 Freeman D, et al., Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006 Jul 1;66(13):6492-6
• All: 13 reference(s)