Prokr1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Prokr1^tm1Lex
• Name: prokineticin receptor 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3653379
• Synonyms: Prk1^-
• Gene: Prokr1 Location: Chr6:87555573-87567725 bp, - strand Genetic Position: Chr6, 38.28 cM
• Alliance: Prokr1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109984
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 with a neomycin resistance gene. Transcript was not found in mutants. (J:109984)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prokr1 Mutation: 23 strains or lines available

References

• Original: J:109984 Negri L, et al., Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. J Neurosci. 2006 Jun 21;26(25):6716-27
• All: 4 reference(s)