Pten^tm2Hwu
Targeted Allele Detail

Summary

• Symbol: Pten^tm2Hwu
• Name: phosphatase and tensin homolog; targeted mutation 2, Hong Wu
• MGI ID: MGI:3653409
• Synonyms: Pten^-
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm2Hwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110567
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of exons 1-3 including both transcription and translation initiation sites was induced by homologous recombination. (J:71874)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm2Hwu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:110567 Freeman D, et al., Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006 Jul 1;66(13):6492-6
• All: 4 reference(s)