Htr2a^tm2Grch
Targeted Allele Detail

Summary

• Symbol: Htr2a^tm2Grch
• Name: 5-hydroxytryptamine (serotonin) receptor 2A; targeted mutation 2, Jay A Gingrich
• MGI ID: MGI:3653427
• Synonyms: htr2a^nr
• Gene: Htr2a Location: Chr14:74878314-74944299 bp, + strand Genetic Position: Chr14, 39.37 cM
• Alliance: Htr2a^tm2Grch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance gene-stop cassette was inserted into the 5' UTR to block transcription. (J:110958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2a Mutation: 43 strains or lines available

References

• Original: J:110958 Weisstaub NV, et al., Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science. 2006 Jul 28;313(5786):536-40
• All: 2 reference(s)