Nisch^edsn
Chemically induced Allele Detail

Summary

• Symbol: Nisch^edsn
• Name: nischarin; edison
• MGI ID: MGI:3653501
• Gene: Nisch Location: Chr14:30892885-30928783 bp, - strand Genetic Position: Chr14, 19.09 cM, cytoband B
• Alliance: Nisch^edsn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C missense mutation that results in the substitution of proline for leucine at position 972 (L972P). (J:244907)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nisch Mutation: 73 strains or lines available

References

• Original: J:244907 Crompton M, et al., A mutation in Nischarin causes otitis media via LIMK1 and NF-kappaB pathways. PLoS Genet. 2017 Aug;13(8):e1006969
• All: 2 reference(s)