Zfp423^tm1.1Ngc
Targeted Allele Detail

Summary

• Symbol: Zfp423^tm1.1Ngc
• Name: zinc finger protein 423; targeted mutation 1.1, Neal G Copeland
• MGI ID: MGI:3653505
• Gene: Zfp423 Location: Chr8:88388438-88686223 bp, - strand Genetic Position: Chr8, 42.29 cM, cytoband C4
• Alliance: Zfp423^tm1.1Ngc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111316
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP sites was inserted just 5' of exon 4. Then an Frt flanked neomycin selection cassette followed by a second loxP site was inserted 3' of exon 4. Mice containing this targeted mutation were then crossed with transgenic mice expressing Flp recombinase under the control of beta Actin. Exon 4 is flanked by loxP sites in the resulting mice. (J:111316)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp423 Mutation: 274 strains or lines available

References

• Original: J:111316 Warming S, et al., Zfp423 is required for normal cerebellar development. Mol Cell Biol. 2006 Sep;26(18):6913-22
• All: 6 reference(s)