Csf1r^tm1Jwp
Targeted Allele Detail

Summary

• Symbol: Csf1r^tm1Jwp
• Name: colony stimulating factor 1 receptor; targeted mutation 1, Jeffrey W Pollard
• MGI ID: MGI:3653514
• Synonyms: Csf1^flox
• Gene: Csf1r Location: Chr18:61238644-61264211 bp, + strand Genetic Position: Chr18, 34.41 cM, cytoband D
• Alliance: Csf1r^tm1Jwp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110981
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed with 3 loxP sites such that exon 5 and a PGK-neo could either both or either be removed from the locus by cre expression. Removal of exon 5 would result in a frame shift that would putatively produce a nonfunctional 244 amino acid product with a molecular weight of 26.8 kDa instead of the ~130 kDa wild-type protein.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf1r Mutation: 67 strains or lines available

References

• Original: J:110981 Li J, et al., Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis. 2006 Jul;44(7):328-35
• All: 11 reference(s)