Als2^tm1Hay
Targeted Allele Detail

Summary

• Symbol: Als2^tm1Hay
• Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, M R Hayden
• MGI ID: MGI:3653518
• Synonyms: Als2^-
• Gene: Als2 Location: Chr1:59202085-59276390 bp, - strand Genetic Position: Chr1, 29.33 cM
• Alliance: Als2^tm1Hay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111035
• Parent Cell Line: mEMS128 (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoter trap strategy was used to replace exons 3 and 4 with an SA-IRES-betageo-pA cassette. The resulting protein encoded from the locus would contain only the five N-terminal amino acids fused to lacZ-neo, thereby inactivating both the full-length and the proposed short form of amyotrophic lateral sclerosis 2 (juvenile) homolog. Absence of protein was confirmed by Western blot analysis of cortex, cerebellum and testis. (J:111035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Als2 Mutation: 88 strains or lines available

References

• Original: J:111035 Devon RS, et al., Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600
• All: 1 reference(s)