Slc6a3^tm1Hhg
Targeted Allele Detail

Summary

• Symbol: Slc6a3^tm1Hhg
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Howard H Gu
• MGI ID: MGI:3653596
• Synonyms: DAT-CI
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^tm1Hhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111041
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP-flanked neo was inserted into intron 3 with the L104V, F105C, and A109V mutations. The neo was subsequently removed from the locus. (J:111041)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:111041 Chen R, et al., Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9333-8
• All: 9 reference(s)