Nkx2-1^tm2Shk
Targeted Allele Detail

Summary

• Symbol: Nkx2-1^tm2Shk
• Name: NK2 homeobox 1; targeted mutation 2, Shioko Kimura
• MGI ID: MGI:3653645
• Synonyms: Nkz2-1^F, T/ebp(fl)
• Gene: Nkx2-1 Location: Chr12:56578741-56583570 bp, - strand Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
• Alliance: Nkx2-1^tm2Shk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111027
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 2 and insert a floxed neo cassette. The neo was subsequently removed via cre-mediated recombination. (J:111027)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-1 Mutation: 24 strains or lines available

References

• Original: J:111027 Kusakabe T, et al., Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Mol Endocrinol. 2006 Aug;20(8):1796-809
• All: 26 reference(s)