Chga^tm1Gnh
Targeted Allele Detail

Summary

• Symbol: Chga^tm1Gnh
• Name: chromogranin A; targeted mutation 1, Geoffrey N Hendy
• MGI ID: MGI:3653689
• Synonyms: Chga^-
• Gene: Chga Location: Chr12:102521228-102531287 bp, + strand Genetic Position: Chr12, 51.66 cM
• Alliance: Chga^tm1Gnh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111025
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exons 1-4 with a neomycin resistance gene. Adrenal expression of the protein was undetectable in mutants. There was no evidene of a read through transcript derived from the remaining exons. (J:111025)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Chga Mutation: 33 strains or lines available

References

• Original: J:111025 Hendy GN, et al., Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol. 2006 Aug;20(8):1935-47
• All: 2 reference(s)