Erap1tm1Iay
Targeted Allele Detail
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Symbol: |
Erap1tm1Iay |
Name: |
endoplasmic reticulum aminopeptidase 1; targeted mutation 1, Ian A York |
MGI ID: |
MGI:3653695 |
Gene: |
Erap1 Location: Chr13:74787692-74841321 bp, + strand Genetic Position: Chr13, 40.48 cM, cytoband C1
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Alliance: |
Erap1tm1Iay page
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Germline Transmission: |
Earliest citation of germline transmission:
J:111047
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Exons 5 and 6 were removed via cre-mediated recombination, resulting in a frame shift that would lead to early termination of the exon 4 exon 7 fusion. The protein if expressed would not be enzymatically active as the active site is in exon 5.
(J:111047)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Erap1 Mutation: |
59 strains or lines available
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Original: |
J:111047 York IA, et al., Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9202-7 |
All: |
5 reference(s) |
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