M6pr^tm1Hlk
Targeted Allele Detail

Summary

• Symbol: M6pr^tm1Hlk
• Name: mannose-6-phosphate receptor, cation dependent; targeted mutation 1, Bernard Hoflack
• MGI ID: MGI:3653697
• Gene: M6pr Location: Chr6:122285679-122294639 bp, + strand Genetic Position: Chr6, 57.52 cM
• Alliance: M6pr^tm1Hlk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111016
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: A neomycin resistance cassette was inserted into exon 2 and the initiation codon was changed to ATC. Northern blot failed to detect transcript in mutant liver, kidney and brain samples. (J:111016)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any M6pr Mutation: 27 strains or lines available

References

• Original: J:111016 Ludwig T, et al., Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes. EMBO J. 1993 Dec 15;12(13):5225-35
• All: 2 reference(s)