Kcnd2^tm1Jmn
Targeted Allele Detail

Summary

• Symbol: Kcnd2^tm1Jmn
• Name: potassium voltage-gated channel, Shal-related family, member 2; targeted mutation 1, Jeanne M Nerbonne
• MGI ID: MGI:3653698
• Synonyms: Kv4.2^-
• Gene: Kcnd2 Location: Chr6:21215502-21729804 bp, + strand Genetic Position: Chr6, 8.49 cM
• Alliance: Kcnd2^tm1Jmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111318
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace all of exon 1 with a neomycin resistance gene. Northern blot analysis failed to detect transcript in mutant brain, heart or liver samples. Western blot failed to detect protein in mutant hearts. (J:111318)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnd2 Mutation: 30 strains or lines available

References

• Original: J:111318 Guo W, et al., Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res. 2005 Dec 9;97(12):1342-50
• All: 35 reference(s)