Efnb1^tm1Rha
Targeted Allele Detail

Summary

• Symbol: Efnb1^tm1Rha
• Name: ephrin B1; targeted mutation 1, Ralf H Adams
• MGI ID: MGI:3653699
• Gene: Efnb1 Location: ChrX:98179736-98192597 bp, + strand Genetic Position: ChrX, 43.22 cM, cytoband D
• Alliance: Efnb1^tm1Rha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110732
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and fused to a human EFNB1 cDNA with a polyA signal. Western blot detected protein from mutants. A neomycin resistance gene was removed via flipase expression. (J:110732)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Efnb1 Mutation: 15 strains or lines available

References

• Original: J:110732 Compagni A, et al., Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 2003 Aug;5(2):217-30
• All: 3 reference(s)