Msh6^tm1Wed
Targeted Allele Detail

Summary

• Symbol: Msh6^tm1Wed
• Name: mutS homolog 6; targeted mutation 1, Winfried Edelmann
• MGI ID: MGI:3653701
• Synonyms: Msh6^TD
• Gene: Msh6 Location: Chr17:88282490-88298320 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh6^tm1Wed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92555
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a T1217D mutation in exon 8. RT-PCR and Western blot analysis showed that the mutation did not interfere with normal gene expression or the stability of the mutant protein. (J:92555)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh6 Mutation: 52 strains or lines available

References

• Original: J:92555 Yang G, et al., Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell. 2004 Aug;6(2):139-50
• All: 3 reference(s)