Nup98^tm1Bmaf
Targeted Allele Detail

Summary

• Symbol: Nup98^tm1Bmaf
• Name: nucleoporin 98; targeted mutation 1, Beatriz M A Fontoura
• MGI ID: MGI:3653729
• Synonyms: Nup96^-
• Gene: Nup98 Location: Chr7:101768607-101859359 bp, - strand Genetic Position: Chr7, 54.71 cM
• Alliance: Nup98^tm1Bmaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110907
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to incorporate a 3-way stop codon at the 5' end of exon 21 and a neo cassette upstream of exon 21 that was subsequently removed via cre mediated recombination. Mutants demonstrated that the unique sequence of Nup96 was abolished and exon 20, which encodes the 6 kDa polypeptide shared by Nup98 and Nup96, was maintained so that expression of Nup98 remained uninterrupted. (J:110907)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nup98 Mutation: 146 strains or lines available

References

• Original: J:110907 Faria AM, et al., The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity. 2006 Mar;24(3):295-304
• All: 1 reference(s)