Csf2rb^tm1Clsc
Targeted Allele Detail

Summary

• Symbol: Csf2rb^tm1Clsc
• Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, Clare L Scott
• MGI ID: MGI:3653883
• Synonyms: betac null, Csf-2^-, Csf2rb1^tm1Clsc
• Gene: Csf2rb Location: Chr15:78210000-78235201 bp, + strand Genetic Position: Chr15, 37.36 cM
• Alliance: Csf2rb^tm1Clsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109889
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: ES cells already containing the Csf2rb2^tm1Cgb mutation were targeted a second time with a vector containing a hygromycin resistance-gene in exon 7 and a TK cassette at the upstream end of the construct. Three different ES cell lines were used to create chimeric mice. (J:109889)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Csf2rb Mutation: 47 strains or lines available

Notes

This allele was created on a chromosome already carrying the Csf2rb2^tm2Cgb allele. Mice homozygous for both alleles are referred to as betac/betaIL3 null mice.

References

• Original: J:109889 Scott CL, et al., Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor. Blood. 2000 Aug 15;96(4):1588-90
• All: 23 reference(s)