Cd8b1^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Cd8b1^tm1Litt
• Name: CD8 subunit beta 1; targeted mutation 1, Dan R Littman
• MGI ID: MGI:3654103
• Synonyms: CD8beta⁰, CD8beta^null
• Gene: Cd8b1 Location: Chr6:71299772-71314476 bp, + strand Genetic Position: Chr6, 32.14 cM
• Alliance: Cd8b1^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112551
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2 and part of intron 3 with a neomycin resistance gene. The result was a loss of 37% of the coding sequence, including most of the immunoglobulin-like domain and the entire J-like region. (J:112551)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd8b1 Mutation: 20 strains or lines available

References

• Original: J:112551 Crooks ME, et al., Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain. Immunity. 1994 Jul;1(4):277-85
• All: 9 reference(s)