Xrcc2^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Xrcc2^tm1Pmc
• Name: X-ray repair complementing defective repair in Chinese hamster cells 2; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:3654106
• Synonyms: Xrcc2^-
• Gene: Xrcc2 Location: Chr5:25894812-25910795 bp, - strand Genetic Position: Chr5, 12.35 cM, cytoband A3
• Alliance: Xrcc2^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111068
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 (75% of the open reading frame). RT-PCR failed to detect transcript in mutant mouse embryonic fibroblasts. (J:111068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xrcc2 Mutation: 17 strains or lines available

Notes

This allele was generated from Xrcc2^tm2Pmc.

References

• Original: J:111068 Orii KE, et al., Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10017-22
• All: 1 reference(s)