Nfkbia^tm1Fey
Targeted Allele Detail

Summary

• Symbol: Nfkbia^tm1Fey
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1, Fiona E Yull
• MGI ID: MGI:3654110
• Synonyms: IkappaB-alpha^-
• Gene: Nfkbia Location: Chr12:55536195-55539432 bp, - strand Genetic Position: Chr12, 24.0 cM, cytoband C1-C3
• Alliance: Nfkbia^tm1Fey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110817
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A 300 bp region containing the promoter and part of exon 1 was replaced with a PGK-neo cassette. (J:110817)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbia Mutation: 19 strains or lines available

References

• Original: J:110817 Chen CL, et al., Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function. J Immunol. 2000 Nov 15;165(10):5418-27
• All: 5 reference(s)