Irak1^tm1Wpfl
Targeted Allele Detail

Summary

• Symbol: Irak1^tm1Wpfl
• Name: interleukin-1 receptor-associated kinase 1; targeted mutation 1, Wai-Ping Fung-Leung
• MGI ID: MGI:3654141
• Gene: Irak1 Location: ChrX:73057520-73067524 bp, - strand Genetic Position: ChrX, 37.61 cM
• Alliance: Irak1^tm1Wpfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110860
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace exons 5-7 with a neomycin resistance gene. Protein was not detected in mutant MEFs. (J:110860)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak1 Mutation: 16 strains or lines available

References

• Original: J:110860 Kanakaraj P, et al., Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med. 1998 Jun 15;187(12):2073-9
• All: 2 reference(s)