Unc5b^tm1.1Dyl
Targeted Allele Detail

Summary

• Symbol: Unc5b^tm1.1Dyl
• Name: unc-5 netrin receptor B; targeted mutation 1.1, Dean Y Li
• MGI ID: MGI:3654305
• Gene: Unc5b Location: Chr10:60598373-60667360 bp, - strand Genetic Position: Chr10, 31.52 cM, cytoband B4
• Alliance: Unc5b^tm1.1Dyl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 to 13 were flanked with loxP sites and an FRT-flanked neomycin resistance cassette was inserted upstream of exon 4. Cre-mediated recombination removed exons 4 through 13 and the selection cassette. RT-PCR analysis confirms the absence of transcript in homozygous mice. (J:111275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc5b Mutation: 63 strains or lines available

References

• Original: J:111275 Wilson BD, et al., Netrins promote developmental and therapeutic angiogenesis. Science. 2006 Aug 4;313(5787):640-4
• All: 5 reference(s)