Ttn^tm1.1Her
Targeted Allele Detail

Summary

• Symbol: Ttn^tm1.1Her
• Name: titin; targeted mutation 1.1, Joachim Herz
• MGI ID: MGI:3654306
• Gene: Ttn Location: Chr2:76534324-76812891 bp, - strand Genetic Position: Chr2, 45.13 cM, cytoband D
• Alliance: Ttn^tm1.1Her page

Ttn^tm1.1Her/Ttn^tm1.1Her embryos fail to thrive after E9

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 358 (MEx1) and 359 (MEx2) were removed by Cre mediated recombination. In situ hybridization analysis confirms the expression of a truncated protein lacking the kinase domain in homozygous embryos. (J:81993, J:111284)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttn Mutation: 1457 strains or lines available

References

• Original: J:111284 Weinert S, et al., M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70
• All: 3 reference(s)