Tg(Myh6-cre/Esr1*)1Liao
Transgene Detail

Summary

• Symbol: Tg(Myh6-cre/Esr1*)1Liao
• Name: transgene insertion 1, James K Liao
• MGI ID: MGI:3654324
• Synonyms: alphaMHC-MerCreMer, Tg(Myh6-cre/Esr1)1Liao
• Transgene: Tg(Myh6-cre/Esr1*)1Liao Location: unknown
• Alliance: Tg(Myh6-cre/Esr1*)1Liao page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Myh6-cre/Esr1*)1Liao expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: This transgene expresses a cre recombinase/ mutant estrogen receptor ligand-binding domain fusion protein under the control of a mouse cardiac-specific alpha-myosin heavy chain promoter. The protein is inactive until induced with tamoxifen. On a C57BL/6 background, the inducible cre expression is higher than that of a similar transgene on a 129/Sv background. The protein is inactive until induced with tamoxifen. (J:109582)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (mouse) Summary of all recombinase alleles driven by Myh6. Alliance mouse Myh6 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:109582 Satoh M, et al., Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7432-7
• All: 5 reference(s)