Ube2n^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Ube2n^tm1Aki
• Name: ubiquitin-conjugating enzyme E2N; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3655236
• Synonyms: Ubc13^fl
• Gene: Ube2n Location: Chr10:95351024-95381520 bp, + strand Genetic Position: Chr10, 49.41 cM
• Alliance: Ube2n^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was place upstream of exon 2 and a third loxP site was placed downstream of exon 4. (J:112287)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2n Mutation: 21 strains or lines available

References

• Original: J:112287 Yamamoto M, et al., Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol. 2006 Sep;7(9):962-70
• All: 13 reference(s)