Alox12b^mmy
Chemically induced Allele Detail

Summary

• Symbol: Alox12b^mmy
• Name: arachidonate 12-lipoxygenase, 12R type; mummy
• MGI ID: MGI:3655496
• Synonyms: 12R-LOX^-, Alox12b^mmy-Bei
• Gene: Alox12b Location: Chr11:69047898-69060617 bp, + strand Genetic Position: Chr11, 42.38 cM
• Alliance: Alox12b^mmy page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A G-to-A transition in exon 14 produces a premature stop codon at amino acid position 633 resulting in a protein product truncated by 68 amino acids. The mutated transcript can be found in the skin of homozygotes. (J:119554)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alox12b Mutation: 37 strains or lines available

References

• Original: J:119554 Moran JL, et al., A mouse mutation in the 12R-Lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier. J Invest Dermatol. 2007 Aug;127(8):1893-7
• All: 3 reference(s)