Krt1^Mhdadsk12
Chemically induced Allele Detail

Summary

• Symbol: Krt1^Mhdadsk12
• Name: keratin 1; Martin Hrabe de Angelis dark skin 12
• MGI ID: MGI:3655853
• Synonyms: dark skin 12, Dsk12, Krt1^Dsk12
• Gene: Krt1 Location: Chr15:101753861-101759221 bp, - strand Genetic Position: Chr15, 57.06 cM
• Alliance: Krt1^Mhdadsk12 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-C transition mutation at codon 194 results in a serine to proline amino acid substitution in the encoded protein. This mutation is predicted to disrupt acidic-basic keratin interactions during intermediate filament formation. (J:108758)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt1 Mutation: 68 strains or lines available

References

• Original: J:108758 McGowan KA, et al., A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis. J Invest Dermatol. 2006 May;126(5):1013-6
• All: 1 reference(s)