Tg(Pcp2-cre)1Amc
Transgene Detail

Summary

• Symbol: Tg(Pcp2-cre)1Amc
• Name: transgene insertion 1, Andrew P McMahon
• MGI ID: MGI:3656031
• Synonyms: L7-Cre, L7Cre, L7-deltaAUG Cre
• Transgene: Tg(Pcp2-cre)1Amc Location: unknown
• Alliance: Tg(Pcp2-cre)1Amc page

Transgene origin

• Strain of Origin: Black Swiss

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pcp2-cre)1Amc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pcp2

• Mutation details: The transgene was generated by placing the L7-deltaAUG promoter enhancer (from the L7-deltaAUG vector in which all upstream ATGs have been mutated) upstream of cre in the pSP-13Cre plasmid. The L7/Pcp2 modified promoter can direct tissue specific expression of genes downstream of it but translation can only be initiated from the ATG of the cre gene downstream of the promoter, resulting in tissue specific expression of cre protein in cerebellar Purkinje cells. (NOTE: A GFP transgene co-integrated with the Tg(Pcp2-cre)1Amc transgene. As such, GFP expression is reported in the cerebellum [personal communication]) (J:92189, J:96313)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pcp2 (species not specified) Summary of all recombinase alleles driven by Pcp2. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92189 Lewis PM, et al., Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004 Jun 15;270(2):393-410
• All: 34 reference(s)