Ptch2^tm1Hui
Targeted Allele Detail

Summary

• Symbol: Ptch2^tm1Hui
• Name: patched 2; targeted mutation 1, Chi-Chung Hui
• MGI ID: MGI:3656034
• Synonyms: Ptc2^tm1
• Gene: Ptch2 Location: Chr4:116953272-116973298 bp, + strand Genetic Position: Chr4, 53.41 cM, cytoband C-D
• Alliance: Ptch2^tm1Hui page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112169
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 6. Northern blot and RT-PCR analysis indicated that aberrant in-frame splice transcripts lacking exon 6, exons 5 and 6 or exons 6 and 7 are expressed from this allele. Mutant proteins with partial function are predicted to be expressed suggesting that this allele is a hypomorph. (J:112169)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptch2 Mutation: 47 strains or lines available

References

• Original: J:112169 Nieuwenhuis E, et al., Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. Mol Cell Biol. 2006 Sep;26(17):6609-22
• All: 4 reference(s)