Tg(Igh-6-Cd80)1Gjf
Transgene Detail

Summary

• Symbol: Tg(Igh-6-Cd80)1Gjf
• Name: transgene insertion 1, Gordon J Freeman
• MGI ID: MGI:3656398
• Synonyms: B7-1 transgene, B7-1T Tg, B.B7-1, T.B7-1
• Transgene: Tg(Igh-6-Cd80)1Gjf Location: unknown
• Alliance: Tg(Igh-6-Cd80)1Gjf page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-6-Cd80)1Gjf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd80 (MGI:101775)

• Mutation details: The transgene was constructed with the Cd80 cDNA containing the complete coding region (but lacking the 2' and 5' UTRs) under control of the Igh-6 enhancer and promoter elements. The construct also contained a mutated nonexpressible segment of the human growth hormone gene included to enhance transgene expression. (J:112474)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:112474 Sethna MP, et al., A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity. 1994 Aug;1(5):415-21
• All: 4 reference(s)