Igk^tm1Rsky
Targeted Allele Detail

Summary

• Symbol: Igk^tm1Rsky
• Name: immunoglobulin kappa chain complex; targeted mutation 1, Klaus Rajewsky
• MGI ID: MGI:3662618
• Synonyms: 3-83kappai, Igk^tm1Pld
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35357
• Parent Cell Line: E14.1TG3B1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector was used to insert a floxed neo (subsequently removed via cre mediated recombination) and a recombined Vk3-83-Jk2 region replacing J1 and J2. (J:35357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 26 strains or lines available

References

• Original: J:35357 Pelanda R, et al., A prematurely expressed Ig kappa transgene, but not a V kappa J kappa gene segment targeted into the Ig kappa locus, can rescue B cell development in lambda 5-deficient mice. Immunity. 1996 SEP;5(3):229-239
• All: 22 reference(s)